Researcher in Population Genetics of Malaria, Group of Molecular biology and Immunology of Malaria (BMIM), at Rene Rachou Institute (IRR), Oswaldo Cruz Foundation (FIOCRUZ-Minas). Ph.D. (2009) in Health Sciences (IRR); Post-Doc (2009-2012) and Visiting Researcher (2012-2014), IRR; Graduate Specialization on Statistics (2017), Federal University of Minas Gerais (UFMG); Post-Doc (2022-ongoing), Karolinska Institutet, Sweden; Affiliate Member of the Brazilian Academy of Sciences (2018-2022).
Contact Info
tais.sousa@fiocruz.br
Office:
IRR, FIOCRUZ-Minas
Av. Augusto de Lima 1715, 30190-002, Belo Horizonte, MG, Brazil
Phone: +55-31-3349-7772
Portuguese: CV: http://lattes.cnpq.br/6108351267696165
English: https://orcid.org/0000-0002-6874-9427
Web of Science ResearcherID: AAG-6225-2019 (https://www.webofscience.com/wos/author/record/1907087)
Research Interests
- Pharmacogenetics of antimalarial drugs;
- Genetic and molecular basis for drug resistance in Plasmodium;
- Alternative molecular methods for malaria diagnosis;
- Genetic polymorphisms in human and the malaria parasite related to susceptibility to malaria.
Relevant publications
Complete List of Published Work:
https://www.ncbi.nlm.nih.gov/pubmed/?term=Sousa TN
Silvino, ACR; Costa, GL; Araujo, FCF; Ascher, DB; Pires, DEV; Fontes, CJF; Carvalho, LH; Brito, CFA; Sousa, TN. Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses. Plos One, 11:e0160172, 2016.
Costa, GL; Amaral, LC; Fontes, CJF; Carvalho, LH; Brito, CFA.; Sousa, TN. Assessment of copy number variation in genes related to drug resistance in Plasmodium vivax and Plasmodium falciparum isolates from the Brazilian Amazon and a systematic review of the literature. Malaria Journal, 16:152, 2017.
Kano FS, de Souza AM, de Menezes Torres L, Costa MA, Souza-Silva FA, Sanchez BAM, Fontes CJF, Soares IS, de Brito CFA, Carvalho LH, Sousa TN. Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria. Scientific Reports, 8:13851, 2018
Silvino, ACR; Kano, FS; Costa, MA; Fontes, CJF; Soares, IS; Brito, CFA; Carvalho, LH; Sousa, TN. Novel insights into therapeutic failure: CYP2D6 activity and time of exposure to malaria modulate the risk of recurrence. Antimicrobial Agents And Chemotherapy, 64:e02056-19, 2020.
Costa, GL; Alvarenga, DAM; Aguiar, ACC; Louzada, J; Pereira, DB; De Oliveira, TF; Fonseca Júnior, AA; Carvalho, LH; Brito, CFA; Sousa, TN. Improving the Molecular Diagnosis of Malaria: Droplet Digital PCR-Based Method Using Saliva as a DNA Source. Frontiers in Microbiology, 13:882530, 2022.